I would think the Sea Otters would be left alone. They do contribute to a healthy kelp forest and a healthy kelp forest contributes to better fishing. Granted, urchins, clams and other shellfish do feel the impact (and those that fish for them).... but I can't help but think that the overall benefit would be positive for WCVI. I did a search, and it looks like the Sea Otters historically were not on the inside. Not sure if they'll make their way in now.
As for the seals, it would be interesting to see if sharks make their way up from California to feed. There are a signficant number of Great Whites that feed on seals off California and Southern Oregon. There were some transient Orcas in Hood Canal a couple years back that took out more than 50% of the seal population in there.... I would think we'll see more of that, hopefully the local pods will pick up a thing or two (especially since salmon is becoming more scarce).